Inderal (propranolol) is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
Weakening the influence of the sympathetic impulses to the b-adrenergic receptors in the heart, inderal 40mg reduces power and heart rate, blocking the positive chronotropic and inotropic effects of catecholamines. It reduces myocardial contractility and cardiac output value. Propranolol slows heart rate, potentiates the action of thyrostatic agents. Myocardial oxygen demand is reduced.
Blood pressure is decreased under the influence of propranolol. Bronchial tone increases due to the blockade of beta-2 adrenergic receptors. In case of sinus tachycardia, it is usually observed normalization of rhythm, including cases of resistance to cardiac glycosides. The drug increases the spontaneous and induced contractions of uterotonic agents. It reduces bleeding during childbirth and in the postoperative period. It reduces intraocular pressure and reduces the secretion of aqueous humor.
Inderal is rapidly absorbed when taken orally and relatively rapidly excretes from the body. Peak plasma concentrations are observed after 1-1.5 hours after ingestion. The drug crosses the placental barrier.
- Coronary artery disease
- Cardiac arrhythmias
- Some forms of hypertension
- Sinus and paroxysmal tachycardia
- Mitral valve prolapse
In order to reduce intraocular pressure in open-angle glaucoma, Inderal is used as eye drops. It is applied in the presence of resistance to other drugs, accompanying arrhythmias and hypertension.
It is also recommended the use of propranolol in the sympathetic-adrenal crises in patients with the diencephalic syndrome, as well as for the prevention of migraine attacks. There is an evidence of the effectiveness of the drug in renal hypertension, in the prevention of postpartum complications associated with impaired uterine contractility. Propranolol is prescribed for childbirth at the primary weakness of labor. Propranolol is also used to treat essential tremor. The drug helps to improve the condition of patients in 50-80% of cases. Also used for the treatment of hemangiomas in infants.
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